Overview
Research Assistant in Leukaemia Epigenetic, DDR and Replication Stress – Strand, London, WC2R 2LS
About Us
Leukaemia and Stem Cell Biology group is led by Professor Eric So, who is funded by the partner organisations including CRUK, Blood Cancer UK, KKLF, and UGC. The group is interested in understanding the molecular and cellular mechanisms underlying the oncogenic conversion of normal cells into AML stem cells, and how cellular and molecular heterogeneity influence the biology and treatment responses of the disease. Currently, we have particular focuses on transcriptional/epigenetic regulation and DNA damage responses. Our ultimate goal is to develop novel and more effective therapeutic strategies for the corresponding human diseases.
The laboratory locates in London, Denmark Hill Campus of KCL.
About The Role
The purpose of this post is to develop and expedite projects aimed at characterizing leukemia networks in leukemia using newly developed disease models in the lab. Transcription factors and their associated epigenetic modifying enzymes are frequently deregulated or even mutated in human acute myeloid leukemia (Zeisig et al., 2012, Cancer Cell). Over the years, our lab has focused on characterization of key transcriptional/epigenetic networks and their emerging crosstalk with DNA damage repair (DDR) mechanisms critical for leukemia development (Kwok et al., 2006, Cancer Cell; Zeisig et al., 2007, Cancer Cell; Cheung et al., 2007, Nat Cell Biology; Arteaga et al., 2013, Cancer Cell; Esposito et al., 2015, Nature Medicine; Cheung et al., 2016, Cancer Cell; Luo et al., 2019, Cancer Cell; Zeisig et al., 2021, Science Translational Medicine; Luo et al., 2022, Molecular Cell,). Details about the lab can be found at https://www.kcl.ac.uk/research/leukaemia-and-stem-cell-biology. Candidates are desirable to have background in areas of DDR, epigenetic gene regulation and/or cancer biology.
This post is aiming to assist Professor So in the design and expediting of his research projects for publication of academic papers and securing of grants.
The post holder will:
- To help to maintain the general operation of the lab.
- To introduce appropriate new techniques and procedures, ensuring that all new techniques and procedures techniques are adequately validated and documented and ensure that colleagues are trained in new techniques and procedures.
- To directly participate research projects.
This is a full time post (35 hours per week), and you will be offered a fixed term contract for 18 months.
IMPORTANT: Before applying for this role, please make sure you have the right to work in the country where the role is based. Unless it clearly stipulates within in the job advert above that the hiring company is looking to or able to sponsor applicants it is deemed that the hiring employer will only consider applications from those able to comply with and work in the country where the role is based.
